. taking ustekinumab�a biologic that targets a different aspect of the immune system," gelfand said..-related side effects. its manufacturer, eli lilly, plans to submit a new drug application to the fda in the second half of 2018... taking ustekinumab�a biologic that targets a different aspect of the immune system," gelfand said..-related side effects. its manufacturer, eli lilly, plans to submit a new drug application to the fda in the second half of 2018..